Gene information
Official symbol ALOX5AP
Official full name arachidonate 5-lipoxygenase activating protein
Gene type protein-coding gene
Chromosome13q12.3
Alias symbolFLAP
Resources
Entrez Gene 241
HGNC HGNC:436
Ensembl ENSG00000132965
Vega OTTHUMG00000016677
UCSC uc001utf.3
GO terms: 34 records
GO Description Category LogP Number of genes Detail
GO:0002532 production of molecular mediator involved in inflammatory response GO Biological Processes -6.20743023 5 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0002675 positive regulation of acute inflammatory response GO Biological Processes -10.8573789 13 More
GO:0005504 fatty acid binding GO Molecular Functions -3.74766542 9 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006691 leukotriene metabolic process GO Biological Processes -6.89692596 7 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016209 antioxidant activity GO Molecular Functions -11.3593886 22 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO Molecular Functions -3.69512980 4 More
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO Molecular Functions -3.76678874 4 More
GO:0019370 leukotriene biosynthetic process GO Biological Processes -4.00389964 4 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031406 carboxylic acid binding GO Molecular Functions -5.96500660 23 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033293 monocarboxylic acid binding GO Molecular Functions -4.50166323 13 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046456 icosanoid biosynthetic process GO Biological Processes -13.7551761 13 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0051213 dioxygenase activity GO Molecular Functions -2.29650667 5 More
GO:0051592 response to calcium ion GO Biological Processes -7.43492702 23 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071248 cellular response to metal ion GO Biological Processes -4.26641514 21 More
GO:0097237 cellular response to toxic substance GO Biological Processes -13.7473733 28 More
GO:0098869 cellular oxidant detoxification GO Biological Processes -12.6410846 24 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04664 Fc epsilon RI signaling pathway KEGG Pathway -4.79120438 7 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
fiboflapon inhibitor TdgClinicalTrialChemblInteractions view
fiboflapon sodium inhibitor ChemblInteractions view
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
ALOX5AP haplotype genomics myocardial infarction[diagnosis] myocardial infarction Helgadottir A et al. Nat Genet. 2004
NM_001629.4:c.[70+18C>A;170+105T>A] genomics myocardial infarction[diagnosis] myocardial infarction Kajimoto K et al. Circ J. 2005
NG_011963.2:g.[21351G>A;29482A>T;53431A>G;57503G>A] genomics myocardial infarction[diagnosis] myocardial infarction Linsel-Nitschke P et al. Clin Sci (Lond). 2008
NG_011963.2:g.49933A>C genomics myocardial infarction[diagnosis] myocardial infarction Gammelmark A et al. PLoS One. 2016
NG_011963.2:g.57503G>A genomics myocardial infarction[diagnosis] myocardial infarction Gammelmark A et al. PLoS One. 2016
NG_011963.2:g.29482A>T genomics total cholesterol[other] myocardial infarction Li Y et al. Lipids Health Dis. 2019
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